@Jason Homa -
Here is my opinion on South Philly from an investment standpoint:
1. Competition - I can tell you that for the past 3-5 years there has been some significant investment dollars being spent in South Philly as a whole. The majority of the spending has been between rehabbing homes as well as new construction mostly in Newbold and Point Breeze. The closer to Broad Street (and the Broad Street Line) the more desirable in most cases. Because of this competition there are fewer opportunities out here for rehabbing/flipping profit.
2. Opportunity - Due to all of this interest, many developers, homeowners, and renters have begun looking west to further Point Breeze and Grays Ferry. Average purchase prices and rents are lower in these areas however are on the uptick.
3. Further Opportunity - I know you also referenced Brewerytown which is not considered a part of South Philly. Brewerytown is developing as well and is found north of Fairmount (Art Museum) area. Other areas that are seeing growth in the Northern Section Philly include Fishtown, Kensington, and parts of Port Richmond.
Let me know if you have any further questions...here to help.
Best of luck!