@Elizabeth Taras
I don't think you realistically will be able to offset the sale of a business by buying real estate.
If I may assume... Many believe that by taking the profits (of the sale of the business) and purchasing something, such as real estate, the profits are no longer taxable. That isn't the case. The profits are still --- profit. You just spent them, and purchase of real estate isn't a deduction by itself.
Also, I don't believe you can do a 1031 exchange from the sale of a business, so you can't defer the tax in that manner.
In terms of how to invest next.. It partially depends on what sort of deals you can find. Also, depends on what are your capabilities and skills. People lose money all the time investing in real estate. Also, while flipping can have a high reward, it also has a high risk. So, you can seriously lose money doing that as well.
Honestly, in what manner to get started is based on a bunch of factors, which I'm not sure if can cover all here. For example, do you already own your own residence? If you are selling your business, what are you two doing for income now (goes toward financing ability)? Are you mobile in any way? etc.
Hope this helps some. Good luck.