Just like saying no because they need a wheelchair.   

My wife being permanently disabled and now requires a wheelchair from being struck from behind.  

An emotional support animal has to be treated like any service animal, which means you can't discriminate against them any more than you could a wheelchair or crutches.You could say, "I'm sorry but we don't allow pets."

It's a ranch home with 3 bedrooms and 1 bath, no close neighbors, and currently has wheelchair ramps into home.

We have a renter asking for a wheelchair ramp. 

Not only was there a paved walkway through the yard of 1 to the neighboring house there was also a wheelchair ramp that connected the houses together.

What happens if a wheelchair bound tenant complained to the city that you weren't accessible? 

At their request, I modified the home for wheelchair accessibility, including widening doors, installing ramp, changing door knobs to door levers, and a major bathroom renovation including a huge wheel in shower ( nearly a wet room).I was able to raise the rent to amortize all the improvements during the term of the 6 year lease. 

She does walk around with a leg brace, a cane, and has a wheel chair.

So, I'd like to find a real estate agent who: 1) Is very familiar with Indianapolis (especially in and around downtown); 2) Is fine working with a client who is buying with a family member in mind; and 3) is disability-friendly, and understands that the top priority will be buying an investment home that is/can be easily made wheelchair accessible.