Just my experience as both a buyer and seller's agent in my area - it could depend on the mentality/culture of the area you're in. 

There are challenges everywhere for different reasons -- weather, building codes, tenant culture, competitive market, high cost of labor. 

Although the nightlife and culture (museums/food/music) was a great and calming change from the busy metro area, I felt isolated.

This is same question why in US we have culture of tipping when other country do not , also why in Us there are just so many added layer fee for attorney , legal and sort of.To be quick , higher commission in US happened because American way of doing business is not efficient, there are layers for law, legal and attorney fee.

Either the culture just didn’t match or it just didn’t feel right.

Consider leaving NYC if you are unhappy with the demanding hours.NYC has a tough work culture - I lived in NYC for 35 years of my life and I been traveling for the past 3 years as a Nomad.People work less hours and are happier in other areas of the world. 

Challenges have been adapting to various cultures and personality types.

Part of it might be cultural but, personally, I don't really mind if I can get myself a profitable deal.

However, because we don’t have much experience with this matter, are relatively new to being landlords, and come from a different culture, we wanted to understand if there are any particular considerations we should be aware of.I heard that it is illegal to ask about religion, national origin, and other personal information when we talk with tenants, even if we don’t have any bad intentions or discriminatory purposes.

Tampa's vibrant cultural scene and proximity to beautiful beaches also add to its appeal, making it a fantastic place to invest.