Hey @Jerry Condra
Multi's that are 2-4 units are going to have higher potential capital expenditure costs (there are 2-4 X the kitchens, baths, appliances, etc than a single family) but will typically have higher cash on cash returns than singles (in most markets). They also tend to have more available rental history since they are all investment properties even if they have one unit owner-occupied so you can feel safer in your revenue projections than a single family.
In my opinion it comes down to how much you have in reserve for capex costs over time and what your inspections of the property turn up on projected life expectancy of the components. On top of that you need to understand the rental demand in the area for the property you're looking at. Multi's can mitigate some vacancy concerns because it's unlikely all units will be vacant at the same time. The flip side of that is liquidity. In most markets, it's a heck of a lot easier to sell a single family than a multi.
That last bit is where my advice would come in: if you're brand new and not 100% sure on all the moving pieces, focus on finding a single family that you can be reasonably sure of all the numbers on and go that route. If you have done some homework on vacancy rates and are comfortable with those numbers (maybe even double the estimated vacancy costs to be safe, again easier on a single than a multi) then I feel that is a smaller risk being able to list and sell that single in a short time frame instead of finding out your multi is a dud and it takes forever to sell down the road. You can always (at least for now) 1031 exchange into a multi down the road once you have more experience and comfort with the process. Or you could seller finance it to a first time homebuyer or several other exit strategies that aren't as readily available with multis. Better, in my opinion, to shoot a little lower on returns in return for mitigating risk on your first deal. After you have one and have been managing it for a while and are ready to pick up something else then multis definitely are the way to go for long term holds with higher returns when the right deal comes across your desk.
Best of luck!