It varies a lot by market, guest type and even the neighborhood and type of home within a particular market. There's no single type of midterm rental property, nor is there a single type of midterm renter. That's a fairly large single family home. The types of renters that would most likely be looking for a 4/2 are usually families with an insurance claim who need temporary housing, families relocating to the area that need temporary housing until they find something to buy or build and construction companies with the need for housing for their workers. For the first 2, location and amenities are key. There are some rougher parts of Euclid which are not going to appeal to either of these types of renters. You might have some luck with construction companies if there's a lot of building going on in your area. Otherwise, rent-by-room is probably your best bet. It's not an uncommon strategy. I try to have my renters meet each other or at least have a phone conversation to make sure they're compatible, but even then, you just never know if they will be. Personally, I don't mix men and women tenants but I know some people do. To me, it's just inviting potential conflict that I don't want.