It is in a downtown environment with access to pubs, highways, etc.

But, it seems like MLS access might not be a huge advantage?

I'm going to make the move to the commercial real estate arena, specifically practicing to become a tenant rep on the buyers side. 

Looking on the internet and I don't seem to find any information about this the only thing that I seem to find is that he has to be less them fight units in the commercial part of the property has to be 49%. 

You will increase your cash flow investing in multi unit purpose built properties and will likely be looking at a commercial mortgage.Purpose built multi unit rentals is you best option to grow your investments and your income. 

I own a house in Portland that happens to be a commercial zone (CM2). 

Commercial, private, or portfolio loans.

The area is close to Newark Airport which is a plus and has easy access to Times Square NYC with a short bus ride.

Would I need a commercial real-estate license to operate it?

My overall goal is to gain enough capital from wholesaling and eventually move to "house-hacking" before my senior year arises and become a buy and hold investor with multi-Families, Commercial Properties, and sharpen my creative real estate exit strategies like subject-to, and eventually doing 1031 exchanges on future properties I own.