Now that we've come 2 years down the line, and those inventories have been depleted, manufacturers are having to kick up production with fewer employees that are getting paid more, and everything costs more.

I think you hit it on the head - depleting your cash is, in my opinion, a calculated risk worth taking due to your savings rate.  

I also pay myself, but I do not deplete the account to a point where I need to transfer personal money back in... unless there is an emergency.

Currently, my largest hurdle/hold up is depleting my cash reserves to purchase land for development.

You can look into an Asset depletion loan or some sort of trust income loan.

You have a lot of unknowns in potential costs in repairs and yet you are considering depleting your available cash to get a place with more room and a bathtub. 

When rates doubled, I did $26M the following year.Realtors who specialize on the buying side are about to be depleted.

If you're already at your max and will deplete your savings just buying the house, I wouldn't get something where you need to do major renos.   

Last year, however, life threw me a curveball in the form of a serious car accident that left me with multiple fractures and depleted my savings and credit cards.

There is also a line (Line 18) for depreciation expense or depletion.