There are some markets that you may be able to make a purchase with what you have available. 

I was lucky enough to have purchased before a surge in the London housing market, so I got my foot in the door for 280k CAD.

Otherwise, you will have to explain the large deposit and possibly the source of the funds to buy the crypto.You can expect to need about 20 percent of the overall costs of the purchase and rehab.

We also have a very strong rental market, and that too has high demand from investors wanting to purchase. 

To add to @Ashish Acharya, I would recommend using your retirement funds for notes that earn a nice interest rate, if you're into self directing.Given that you want to purchase a short term rental, I'd highly recommend not doing this within an IRA/401k. 

Is this purchase on the MLS or through a turnkey company? 

This sounds like a home run and a great first purchase!!

I recognize that when my family visits I'm hurting my profitability, but that would be once or twice a year and its part of the selling point to my wife to purchase a property.Where I need help is running the numbers. 

Also note that when you formed/purchased the LLC, you weren't married yet. 

I live in San Diego and am trying to purchase my first investment property I have about 150K to put down but am struggling to find deals that meet my price point.