There are pockets in Greenville that could experience good rent and property value appreciation to compensate for the poor ROI on your existing house as a rental but you have to be in one of those pockets (downtown, etc.) and this strategy should be intentional and data supported rather than accidental.  

The vast majority of the commercial brokers were over an hour away from me in Downtown Tampa, FL. 

They are also business for profits which tells me that's where to keep an eye out as locations closer to downtown tend to have premium pricing on real estate.

I'm an agent here specializing in Downtown.

I am looking in the downtown area as well as east campus and West A neighborhoods, but I am not married to any of these neighborhoods.

Even with $100k down, you'll probably be priced out of any 3- or 4-family properties that hit the market anywhere in Downtown JC.

I am in the downtown region but was born in La Mesa, It's a great town.

Welcome to BP.If you're starting out and looking for places to invest I'd recommend ignoring downtown/midtown.  

I currently live downtown Chicago and I'm originally from the west side of Michigan (near Muskegon) so I thought this location may be a good spot to dig into and get my first rental property. 

Grew up in plano and currently live 8 min east of Downtown Dallas.