This isn't much of a drawback though since it usually doesn't make sense to put only 10% down on a rental unless it is a cash cow.

The drawbacks here are that you may only be provided a line of credit for 70%-80% of the home's value, leaving some money still in the previous deal, and the interest rate on a HELOC may very well be higher than a conventional loan.So, to address your initial question, you really need to ask yourself what you hope to accomplish. 

The drawback is trying to make the windows, doors, and any other penetration look good and not recessed into the siding. 

Are there any drawbacks to being a real estate agent and managing own properties?

Are there any other drawbacks to Section 8 besides the fact that they have a stronger likelihood of trashing your place and that you have to work with the government? 

The only draw back to this is you’ll have to pay a little more in fees but in my opinion it’s worth.

The drawback is you don't get much of a discount on the price and you'll likely be looking at B type neighborhoods so the price might be a little high.

My two main concerns are I'm starting late in my fifties and definitely not very handy so that's a drawback.

It's brick (visually in good condition but I'm not an expert) with hardwood floors (need refinishing), with some serious drawbacks: both bathrooms needs to be gutted and remodeled, kitchen needs updating, last occupants left SO MUCH CRAP behind (seriously the 5 mattresses are the least of it).

You're only other option is rolling it into a self directed IRA and using that to invest in real estate but there are drawbacks to that as well, and you'll still owe tax on your 401k loan balance