South Knoxville is were the young professionals, such yourself, are moving. As Jacob mentioned there are a lot of attractive things about this area (Ijams and the Urban Wilderness, 5mins from downtown, breweries, near UT for gamedays, larger lots, county taxes potentially, etc, etc). "SoKno" now also fetches some of the highest $/sf in Knoxville. Rivaling even our old money luxury neighborhood, Sequoyah Hills. So you'll need to stay in the small square footage to stay around $150k (think 700-1000sf rehabbed) but there is opportunity to buy houses that need work. Those small houses make great rentals and you should see strong appreciation and rent growth there to boot.
SFR's are great, the most secure real estate asset to own imo. Consider a 2-4 unit as well though and live free from day 1. They are harder to find anymore but I got started with a duplex myself and it was a huge boon for my career and today is a cow. Real estate is about the long game, think 2-3 steps ahead with each decision, focus on the end goal, and you'll get where you want to be.
Feel free to reach out with any Q's about Knoxville or investing. Welcome.