Hi Eric,
I'm transplanted from So Cal living in Springfield, MO, which is a good area for cash-flow properties. Reasons are - relatively stable economy and job growth, several Universities (Missouri State, Drury University, Ozarks Technical College, Evangel, etc.) in the local area and a major hub for surrounding suburbs/towns such as Ozark, Nixa, Republic, etc.
If you favor cap rates, it is easy to hit low to mid double-digits on properties that seldom top $100K (yeah, BIG difference from Irvine/SoCal in general!!). If you are comfortable with leverage, cash-on-cash returns easily start at 20% and go up from there.
Appreciation will be little to none, or basically keep up with inflation. Unless there is another spike or access to easy money that we had back in the early-mid 2000's.
After living here for several years, I will continue to acquire properties here for cash-flow and flip properties in So Cal. Bottom line, though, is it's much easier on your capital reserves to build a portfolio of cash-flowing properties here in the midwest.