I haven't done this, so this is just my thoughts and not experiences. I would run them just like a regular tenant. Do background and credit checks. One other thing you should consider is writing out every rule you want them to follow, and be sure to be up front about them. Sharing spaces can get tricky and you want to be sure there aren't awkward situations right from the get-go. Rules about use of kitchens and common areas, visitors, quiet hours, etc. If I were renting out rooms in my house I'd probably provide them with a mini fridge and microwave. Maybe even one of those conduction hot plates (they don't actually get hot). That would allow them to do simple things in their room and it would be more like a studio. Do they have their own bathrooms? Maybe rules about shared bathroom spaces, etc. If it's just you (not married, no kids) then maybe stick with renting to just men. That way you won't have to worry about lots of bathroom use or awkward men/women situations.
Good luck!