The big issue I see is the explosion of out-of-state investors who are trolling the Indy market, trying to jump in. They're driving the prices up in many of the B neighborhoods. As a result, the smart REI investors are looking for B-minus or C-on-the-borders-of-B areas.
Fountain Square is the neighborhood where a lot of REI's [including ME] are trying to find properties - thanks in large part to HGTV's "Good Bones". It's the kind of neighborhood we all dream about: high 'walk score', safe feel, coffee shops, theaters, low crime, high rents, and LOTS of renovations happening on older homes all summer long. I've been trying to find a good buy in Fountain Square since February, but the one's I like are all overpriced, or are snapped up more quickly than I can arrange financing.
I'm also interested in Irvington, Emerson Heights, Little Flower (thanks to the 10th Street redevelopment org), and parts of Crown Hill.
But it's a street-by-street thing. Your best best is to look at BOTH the sale price, and the rental estimates on houses surrounding your target properties. And make sure the houses fit your 'criteria' (me: 3br/1+bath, supporting $1K+ monthly rent, bought @ 20% below market).