I would move from San Diego, and return when it becomes affordable for whatever reason. For example, I wish I lived in Silicone Valley but why live somewhere that I will have to live paycheck to paycheck. Instead I live about 1hr 40 mins away and commute out there to make the big bucks. It's a short term sacrifice but I have a lot of money to spend on leisure, instead of worrying about a mortgage payment or my rent. Rent out there for a house like the one I live in would cost me about 5000 a month, and here in Modesto I'm paying 1600 on my mortgage while building equity. I'm thinking in the future, God willing I can sell this one and put a big down payment out there. As for now I live alone with my family and don't have to worry about having other roommates to help pay my rent or mortgage. Just my opinion, but do whatever you think works best for your situation.
