Blending LTR and MTR on the same property

[Taylor R Herschleb]

I am currently under contract on a duplex. The main part of the house is a 3/1.5 and it consumes the front part of the building. The back of the building has an attached studio "cottage". I am thinking that about setting the the 3/1.5 up for an LTR and then furnishing the studio to use as an MTR, since the property will be 1-2 miles from one of our major hospitals. Has anybody ran into any issues with blending their property as a LTR and an MTR?