Quick MLS question

[John D.]

I found a potentially decent deal on the MLS. The property is listed as a "handymans special" and has been listed for roughly 200 days. My question is to save time, would it be advisable to reach out to the listing agent and ask if the seller would be willing to accept a substantially lower price than what they have listed? The price is pretty low now but there is probably $30-$40k in work to be done.

Any info is appreciated.  Thanks