I want to buy a building but.......

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What are some reasons why you wouldn't purchase a building?  Over time, I found many outlying factors that would turn investors away, however, in the back of my mind, I still consider this thought often; someone is going to buy it eventually, so why pass it up.  Even if there's a lot of work to be put in, someone somewhere is going to have to "bite the bullet" and do it eventually so why wait? I know the logical answer but I would love to hear people's thoughts or past experiences!