I have a high income producing beach rental duplex that was purchased after the accelerated depreciation start date in 2017, I have a high paying W2 job in medical sales, and my wife is a real estate professional, with 1099 income, so it seems ideal to write a lot of this off.

The lower area consists mostly of lower income houses but has many 4-15 units all over for the reason of its proximity to the medical area. its right by 2 main hospitals.

Like a strip mall, medical building then a bunch of homes?

For medical care, people can get home health care, so as to stay out of the assisted living designation, requiring licensing, etc. 

Purchased a rundown 6-plex in Houston for $235k near downtown and the TX medical center. 

There are exemptions, including the one where you can use the rent money for medical expenses .

Furnished Finder recently stated that searches by non-medical professionals just exceeded searches by medical professionals for the first time ever and they expect that trend to continue.

I personally like STR/MTRs around hospitals (specifically Nationwide Children's Hospital, Wexner Medical, etc) because you're able to find a stable cllientele of travel nurses to rent to and they get stipends which is guaranteed payment and they're typically great tenants.

However, searches by non-medical travelers has now surpassed medical travelers and they are predicting that trend will continue. 

@Ehlen Baylon love that you're a medical professional and doing this...so many don't!