The biggest differences will be the taxable situation.

So today I was talking to my mentor and we were considering different real estate strategies to expand my horizons.He mentioned mixed-use properties, which I honestly have never considered as an investment.

You also have to look at a few different things. 

If one does not do their due diligence and test for hydro-static moisture, the plank could release in different areas causing heaving of the installation.

Are there common resources out there that would have foundation statistics about different neighborhoods?

This forces people to move to a different city to find work and start over.

Another thing to learn is that different markets have different characteristics. 

Start growing your network, look on Facebook/BiggerPockets for different events, find a mentor doing what you want to do, and get to know the local lenders/brokers.

I suggest having someone who knows the market walk you through the different areas in our markets.

So, I'm addressing a primary home with a different perspective.