It can be substantial.

The Fed Gov Chris Waller addressed those charges a few days ago and (not surprisingly) citing the Feds complete autonomy as still intact and free from political influence.

If you buy/have a performer that is well seasoned and has a borrower with a substantial ability to continue payments, you can sell a "partial" of X amount of the future payments for a set return to the partial buyer, then take that capital from the the partial sale and buy another note, sell a partial, reacapitalize, etc.

Briefly speaking with the tenants it became evident they had developed a substantial drug habit.

You will needs substantial cash reserves, very little (none is better) bad debt or your debt to income ratio will be disqualify you from getting that mortgage, you will also need to have a large down payment (20% at least) if the property isn’t your primary residence.

I'd assume you can earn substantially more ROI than the interest and future closing costs by leveraging the extra $300K to earn more rental income (or another investment vehicle).

This may not sound like a substantial amount, however 752/60=12.5%.

You are not in the business long if you let emotions influence your decision making.Let me put it another way, using your own example. 

Spend time searching for an hiring an experienced contractor who regularly works with investors and has deep networks and influence within the city permit-issuing departmentsGood luck with your first or next multifamily deal, and we hope this article helped you out in some way! 

Sounds like you got some substantial appreciation over the past few years.