Mixing family and business is a horrible idea.  

Now most people are going to keep other investments in the mix but for the people trying to invest in real estate for the purpose of owning their own life, I can see a much larger segregation of cash into that bucket.

@Lingo Lin, Tenants by the entirety is available ONLY to married couples as far as I know, you are mixing the homestead exemption I think with it. 

I have with mixed results. 

Mixing family and business is dangerous, especially if that family is desperate. 

Important you consult  your accountant,  but it's my understanding you use the Heloc strictly for the investment & do not mix personal use with the investment use so the interest is tax deductible. 

I've read a few posts on "wholesaling" and now I'm having mixed feelings about it.

@Danielle MasseyI’m a commercial real estate agent in NY and I own one mixed use and one 5 unit.

Now add an ESA to the mix.

I'm happy to share his info if would be helpful.Again, remember you can't mix a conventional loan with a hard money loan in most situations.