What digging I've done has been in valuing professional services practices (same issue: owner does the "labor", has client loyalty, etc.) as well as medical practices (patients loyal to a doctor more than a physical address).  

See medical/nutrional/fitness professionals, do a biometric screen, and log everything in MyFitnessPal. 

Lets call that the :( side.2) And there is the happy side... passive income (syndications, passive partnerships ie medical/dentist offices) and passive losses (depreciation, bonus depreciation via cost segregations common in syndications).

House is in the 77021 area, 8 mins from the medical center.

I know people paying cash in multiple states so theoretically it "cash flows" but I'm not a fan of paying cash Can you do MTR or STR in Fresno to traveling medical workers or corporate professionals so you have less negative CF vs.

In early December last year, one of their children had a medical emergency in the house and had to go to the hospital.

I would not go online to get medical or legal advice from randoms. 

It's close to the freeways and medical center.

Plenty of tech companies are heavily investing in the area and we already have large established universities and medical facilities 

Travel medical professionals, and other MTR travelers, are only stating for a few months and will likely pass on your home if they have to set up utilities.