Build a strong team, prioritize cash flow, and take the time to understand the local market and regulations, especially for development projects.

BUT know your jurisdiction's regulation on screening.

A good property manager can help with tenant screening, enforce lease terms, and handle evictions more efficiently if it comes to that.Require a Larger Security Deposit: Within the bounds of local regulations, a larger deposit can provide a cushion in case of damage or unpaid rent.Consider Rent Guarantee Insurance: Some companies offer insurance products that can cover lost rent in case of tenant default.

And the changes, such as regulation, city development, traffic flow, building views etc happen very quickly. 

Definitely follow the regulations in the area and if permissible I would offer to attempt to find an acceptable tenant and terminate their lease when that happens but in the meantime they will need to continue to pay.

As much as I hate government and regulation, this kind of BS is why we have it. 

Can regulations change?

@Eric Andersen definitely put weight into what @Michael Baum wrote and do your own research on the city regulation/zoning.

I've been corresponding with a non profit in CA that is doing work on ADU regulations, etc.

If I were to guess, I would think that the new administration will bring positive change to the housing sector by removing regulations that impede builders, and affect building material costs.