My goal is to amass wealth and donate it to physics when I die.

At closing there is nothing wrong if the real estate agent offers to buy you dinner, and after you finish dinner, the agent said I like to donate $1000 to your son's birthday party.

If my own brother, immediate family, or close friends came to me calling for help because of this situation and they are otherwise hard working individuals I would help them with little hesitation if I had the means to do so for the situation.I donate money to causes that I care about for charity.

Then that money is put thru the "Double the Donation."

In some areas, you can donate the house to fire dept for training/burning.

A) Itemized deductions is not only mortgage interest but also real estate taxes, charitable donations, medical expenses, etc.B) mortgage interest and real estate taxes, as it relates to itemized deductions, is only on the personal residence side of a house-hack.Therefore, it needs to be prorated.C) if you buy at the end of the year, your mortgage interest / RE taxes will be small since it will be only 1-2 months worthYou will most likely take the standard deduction for 2022

As my biz associate is able to donate the income he would make to our project.

Would I really rebuild or would I be better off tearing down the property and selling or donating the land?

We donated to a fund to help the residents and someone was generous enough to be matching donations.  

If so I’m thinking she could make some sizable donations which would lower her taxable income to below 47000$.