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If you look in sub markets of larger cities mostly around the South and Midwest it can be achieved more at scale. 

Would the mortgage interest costs be deducted from the return achieved from the invested funds that would have paid off the mortgage?

Because the 401(k) is an employer plan instead of an Individual Retirement Arrangement, many of the plan-side features are more powerful, such as higher contribution limits, the availability of participant loans, etc.Structurally, you can achieve full checkbook control over either an IRA or a Solo 401(k).  

If the house is located in prime area, perhaps STR would makes sense with some tax loopholes that you can achieve and save.

Nobody tells you how to achieve the second phase of the project, the sale of the property—which is the whole point of the exercise.

In other words, even with a better rate of return, starting later can influence when you achieve the same end result.

Multi-family can work out but if you're marketing to travel medical professionals, many of whom work nights and sleep days, you'd need to be able to provide a relatively quiet space and that can be hard to achieve in multi-family properties.

“Alone we can only accomplish so much, but together we can achieve anything.” 

It gives you valuable experience as a landlord firsthand which will be helpful down the road when you consider a BRRRR strategy with hard money.