Are there any concerns to vaping indoors?

If that's the case for you, I would check to see if your town has an ordinance allowing accessory apartments. 

https://www.tampa.gov/city-planning/accessory-dwelling-units#:~:text=Tampa's%20code%20allows%20ADUs%20to,residence%20must%20be%20owner%2Doccupied. 

I am considering making an offer on a property in Atlanta zoned as single family with an accessory dwelling unit (basement unit with private entrance).

That means you can buy a home with a main floor and basement, convert the basement and if there is enough space build out an accessory dwelling unit (ADU).

@Jonathan Feliciano Something to look into as an option is if your jurisdiction allows accessory dwelling units or ADU's in your zone.

AirBnb for example may have more folks seeking luxury amenities with their stay becuase they have been sorta conditioned to expect those things with the AirBnb brand; rather furnish finder you will still find room to room rentals just looking for a private bedroom and bathroom, and that is it.I run a MTR for traveling medical professionals so my basement ADU is packed with the meal prep kitchen appliances and accessories to help with their long 13 hr shifts.

I understand no smoking, but no vaping?

Collier County put out a notice recently that states:"In most Zoning Districts that allow dwelling units, transient lodging (less than 6 months) is not a use that is listed as a permitted, accessory, or conditional use in Ordinance 2004-41, as amended, the Collier County Land Development Code.

I wish other angles to increase housing supply were also being explored in Boston...they started an accessory dwelling unit expansion "pilot" program but i think it only included 2 neighborhoods.