All of my clients are pretty much millionaires to multi-millionaires.The larger box sizes of 60k to100k sq ft if in a good location will easily get re-adapted with a new tenant or mixed use.

(Though there was much more wrong with him than his inability to adapt to the 21st century of business)

I understand that someone who does not meet your ideal rent-to-income ratio is likely to have one other legal screening criteria unmet, but have any of you run into problems with this?

He sold the park because he could not adapt to market conditions as fast as I could. 

I agree with @Joe Villeneuve If your business is lending, lenders will adapt to the market.

Oh, I only heard this several times every one of those 28 yearsAdjust, adapt and overcome !

Your first lap will generate heat/vibrations that will hatch the flea eggs (an evolutionary adaptation they have), and the second trip will allow them to jump on your legs. 

Things change and you have to be able to adapt and overcome.

I might just adapt the same.

Adapt and overcome.