@Derik S. I think it comes down to your goals which leads into the business plan question. If you are the person who has some cash to invest and doesn't want to be involved in the day to day or month to month interaction with the tenants then investing out of state may work for you. As others have said you have to have a team on the ground that you can trust. This could involve some out of state travel to drive the areas, meet with people, etc.
Personally, we don't have an official business plan (we only have one rental now) but we do have a few spreadsheets that line out our goals, rentals, etc. This is just to have a general roadmap of where we would like to be in 10 years (ie-number of rentals, income, expenses, payoff, etc.) We don't want to get caught up in the details of future properties. We know our goals and minimum criteria for purchasing another rental and when we find one that meets our criteria then we buy it. (This has only happened once but we are close to rental #2)
I am not familiar with the Fort Collins market but it seems that you could find some areas within 1 hour that would have a cheaper price point if you wanted to be more involved in the rental. We are in Firestone and while I don't know for sure but I am assuming that it is a cheaper market. There are a few smaller towns not to far east of I25 that are cheaper but are "bedroom communities" to Fort Collins, Loveland, Longmont, etc. that are cheaper but current rents are high. 15-years ago I was told and I think it still holds true...if you want to find cheaper housing just go north and east of Denver.
This is just my 2 cents. Good Luck! I am sure you will do well since you are asking the questions.