Jason - this is a bit of a specialty for me right now and I'm actually completing development of a 10,000 sq ft facility that I acquired in Jan 2018.
It was listed on the MLS as a 1 acre parcel with a manufactured home. I knew the highest and best use of this property on a commercial corridor was going to be office of some sort. I acquired the land and began speaking with various economic entities in the area. They confirmed that they needed more space, so I felt comfortable moving forward.
I got connected with a Realtor that specializes in medical commercial space. Within a month or two of working with this broker, I had a 7 year tenant leasing 70% of my space before we turned dirt.
I'm actually in the process of writing a book to capture the basics of getting started in TRUE commercial space and would love your feedback in the future. I think commercial is one of the best asset classes because of the long-term nature of leases, less wear and tear on the buildings, and the ability to pass along costs via NNN leases. By the time my first lease expires, and they have an option to renew, the building will already be half paid for because I'm choosing 15 year amortization.
The best thing that you can do is find what are known as "Economic Development Corporations" in your area. They may not be called that specifically, but they are a semi-government organization that works closely with city council to make sure that they are encouraging and helping economic growth in the area. They are aware of businesses and other opportunities that want to come to the city and they can help connect you with the companies that need space. This is how I was able to move forward without speculating very much. You should also get familiar with the planning and zoning maps that your city offers so that you can see where they are projecting the growth to go and how you can plan to be in the growth path.