I can't speak for other large cities, but crime in Chicago just can't be generalized even neighborhood to neighborhood. It's more like block to block, and depends heavily on how close knit residents are. You could have a building on one block and have no issues, and the next block over may be nothing but problems. Like Marqueen said, Chicago is very segregated, as are most post industrial Midwestern cities, and there is no general answer in playing it safe, such as staying north of I-290. Neighbirhoods here are constantly changing, and it takes local street smarts to know what the nest move to make is. Areas that 5-10 years ago were borderline uninhabitable without being a victim of crime, are now the cities most popular and sought after markets. Bottom line is there is absolutely no way to make an educated decision on investing in a new market without either you physically experiencing and scoping out potential target areas, or working with someone local who works all areas and knows the difference and can help you avoid costly mistakes driven by appealong price points