That is a good bottom line of looking at the future, yes. If interest rates are basically at 0 then there is only one way in the long run: up. And they will go up, no doubt. Whether it's a (small) hike in December or only in January, we'll see.
Then again, a .25% rate hike will not have much of an impact. Do the math: let's say you, as a consumer (not investor), finance your primary residence of 200k with 5% down, i.e. you need 180k from the bank. Further assume that currently you will get that amount for 3.5% interest rate (per annum). That's an annual interest payment in the amount of 6'300. Per month that's 525.
Now calculate the same with 3.75% because that's how much the bank increased the rate due to a .25% rate hike by the Fed (this is very simplistic and will not translate 1:1): total annual interest is now 7'200, that's 600/m. That's an additional $75 per month on a 200k property. IF this breaks the bank for you on that property then you shouldn't have bought it and financed it the way you did. At least in my opinion.
Now look at a typical investor, because there will be a difference. Why? You will never get by with only 5% down. More realistically it's 15-20%. Why is that relevant? Because you will need a smaller loan on that 200k property. You can run the math yourself. Bottom line: the difference is negligible in this context. And since these things are relative, it also hardly makes any difference when the figures get bigger. Because then you would have, overall, typically more money somewhere and wouldn't be bothered if the difference was tenfold. Again, simplifying things.
Long story short: such a small rate increase will not make a noticeable difference. But the .25% will only be the beginning. It will continue (in that regard I'm with Bill) and at some point we'll have - overall - some .75% or even 1% in the next couple months. And that's when things will definitely start to have an impact. The impact will be as Bill has described above.
Oh, and that's perfect for me as an investor as this only means more inventory for me to chose from as fewer people will be able to get financing, therefore less people will buy houses (= more for me) and might even have to sell (=even more for me to chose from) (leaving aside a delayed decrease in new construction). And how can I afford to still buy with increased interest rates? Because I don't leverage up to my eyeball and my ("cash-flow") figures work out.
I would even go as far as saying (again, somewhat simple): a serious real estate investor doesn't care much about interest rates. But that might be a somewhat bold statement. ;-)