This is what your question sounds like to me. I want to start playing poker, but I don't have any cash. Should I borrow against my home to play my first game of poker? If I do this, should I bet all of my money on the first hand, or make smaller bets until I learn the game better?
My advice is to take small risks in the beginning. You have an expensive home, so I assume you have a pretty good income. I suggest that you set aside some cash for the sole purpose of buying a rental property. While you are saving, learn more about your market. The "low income high crime" areas will give you a bigger ROI. The nice suburban areas are lower risk and also lower ROI. You will need to find the area where risk and reward are acceptable for you. Tip: if it's listed with a Realtor, it is over priced as an investment. Find a house in distress where the seller needs to sell. When you buy it at a lower price, they will be thankful that you rescued them. If you are going to make a mistake, and we all do, don't put your home at risk or borrow at 8% for that mistake.