How to track mass mailing lists

[Jordan Bishop]

I am curious if anyone has ideas, methods, or advice on how to track mass mailing? 

Let say the list i am mailing to has 3000 names, and out of those 3000, 50 call back how do i track that to not mail to them again?

Also if i pull a new list every month, but the homes are not guaranteed to be updated.. how do i track not sending to the exact same home twice?