How to differentiate personal and business expenses

[Jantsen Locke]

Just closed on my first house hacking deal (duplex- living on one side and renting the other).  I know there are some tax advantages involved (currently my next reading topic). It makes sense to me that opening a separate bank account would help me distinguish business related receipts from personal expenses. 

Is this the right thought?  Also, is there a credit card that anyone prefers because of the perks or any kind of other information in relation to this?