minimum requirements for non smoking but get a snoker applicant

[Don Spafford]

I just posted my first "for rent" online and in it set the minimum requirements and even in the property information disclosed that it is no smoking. I got a message from an interested person through trulia and in the thing they fill out online mentioned that they are a smoker. 

Should I just ignore it or do I respond and tell them already that they don't meet the minimum requirements. Or do I still have them fill out an application? I don't want them to pay for the background check knowing I won't rent to them. Or should I just call them and qualify them over the phone and restate the minimum requirements?