As interest rates rise, how does your business change?

[John W.]

This is assuming interest will continue to rise. For me, my long term goal is to own doubles in my A neighborhood,  that currently are 150K +. And 5% + interest starts to really cut into the profits. I'm not real excited about potentially having to pay close to 10K in interest a year in the coming years. I'm conservative by nature and like low debt and low risk, but also realize this can limit you from scaling up. I would like to gain more understanding in this area. 
Seasoned investors, how do you view interest rates?
And how do you adjust your business accordingly?

I just watched this gem of a biggerpockets podcast:
https://www.youtube.com/watch?v=pvow1ifO3Qk

And the guy said 3/4s of the way through the podcast that appreciation rises a long with the interest rates which I thought was very interesting. 

Thanks in advance
-John