Offsetting 401k withdrawal taxes

[Irving Franco]

Is away to offset the income tax on a 401k withdrawal that will be used to purchase investment real estate. I know I can move the money into a self directed IRA and going that route, but I'm curious if you can take a 401k withdrawal and use other tax losses within the year to offset the income tax.

I live in California which has higher income taxes, I have a W-2 job and do not qualify as a real estate professional