Single Family or Multiple Tenants?

[Dan Jones]

In my area there are multiple single family houses that have 3+ bedrooms and living area enough for a multiple individuals but would be a smaller market for a single family (I.e. the family would either need to be fairly large or convert the extra bedrooms into a different type of space).  When renting out a large (1500+ square feet, 2+ bed/bath) single family home what is the better strategy to take: rent to a single family or rent to two or more individuals?

Are there legal or ethical questions that should come to mind or is this purely financial?

Should I focus only on smaller single family houses?  What are some strategies to fill a bigger single family house?