Can I use 401K to buy/move out from primary home? Tax penalty?

[Josue Vargas]

Can I use my 401K without tax penalties if I want to buy a second property with the intent to live in it?  

How about if I move out from my primary residence, rent it, and then purchase RE for my primary residence? Can I use the 401K for purchasing primary residence without tax penalty even thought I have a mortgage on another property that I will use as REI?

Thanks for your help.