How to decide on a OOS property to invest in?

[Jessey Kwong]

Since I'm looking across the border (from Canada) into the USA, I will need to invest in a city that I have not much information on (at least not yet). Planning on a Buy and Hold.  But how does one decide on what city/state to invest in?

What factors must I consider before focusing on a city/region?

Given - I don't have much of a network (at least not yet).