Loan amount and interest question over the long term

[Christopher Davis]

Hi, Newbie here. At the moment I am reading The Bigger Pockets book Rental Property Investing, getting the basics down. I am also starting to analyze some properties in a particular market. I have a general question about loans.

Let's say its a conventional loan for 300k, 30yrs, at 4%, that comes to a monthly payment of $1,432.25. 

Total interest $215,608.52, total loan $515,608.52.

A total loan cost of $515,609 is a heck of a lot more than the initial $300k.

My question is, what would be a strategy to mitigate this overall long term loan cost? Would you ideally sell the property in a few years so you're not actually realizing that total loan cost? Would you just say no big deal as long as the monthly payment is made? 

Obviously I understand the bank needs to make money. So I'm wondering how an experienced investor would view this, and what could they do to mitigate this over time? What would be a strategy to try and limit this total cost?

Thank you very much for any guidance!