When is a mortgage a good move?

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As an aspiring full-time real estate investor/investor, should I take out a mortgage on the home I want to purchase before or after I begin to purchase rental property? Should I wait until I have a substantial amount of generated income from properties I have purchased where I can afford to continue the acquisition of new assets and pay a mortgage on a home? I am trying to get an idea of the best moves to make after I pay off my consumer debt and student loan debt.