Do you have thoughts on the "class" of neighborhood and overall safety?

But I would not do multiple background/multiple genders folks as room-mate as there would be higher safety issue and continuous drama.Also if you can, try to find property where you can divide the wall, and add bathroom/walls/kitchen,etc.

Make sure city in which this property is located that you check with the city if they require any permits and if this particular property is current with all health and safety inspections.

as a first time investor and going out of market.figure out a market  figure out the median price point for the SFR you want to buy and buy at or slightly above that .. this will get you in the safety zone.don't buy in a market were the median is say 150k and your looking at 100k houses. those will be life long renters tough to manage and tougher to maintain. 

Perhaps there's some way of having her declared a risk of harm to herself and others and removed from the property for her own safety.

Ensuring that all work is done to code and obtaining the necessary permits is essential to avoid potential legal and safety issues down the road.To find reliable contractors or subcontractors, consider asking for recommendations from fellow investors, real estate agents, or local real estate investment associations.

If they have some accessibilty or safety upgrades they may need treat them like any medically necessary requests.

By 'danger' zones, I'm assuming you're referring to crime/safety? 

I express the situation in their interest--getting behind on rent, risking a possible eviction is not helping you, but moving out and finding a safety net and getting your deposit back and a decent reference is.. 

If your down stairs patios have fences, you might consider cutting the fences down to 4 ft height so as to let more light into the units in addition to safety concerns.