For example, in my state, anything over 10% interest on an ANNUAL basis (APR) is usurious (illegal) unless I go through a broker or there's some other limited exemption that the loan qualifies under. 

Lets call that the :( side.2) And there is the happy side... passive income (syndications, passive partnerships ie medical/dentist offices) and passive losses (depreciation, bonus depreciation via cost segregations common in syndications).

She isn't disabled by the illness, not covid - just needs medical attention.

See link in my comment above for the list.Leverage in an IRA will result in Unrelated Business Income Tax, leverage in a 401k will be exempt from this tax. 

The materials were exactly the same and didn't account for updated medical laws, so the information was outdated. 

I’m a 27 year old medical device sales rep who wants to build passive income and quick the 9-5 grind asap lol.

But truly self-directed Solo 401k is exempt from such tax on leveraged real estate.

I really need the funds though, I'm living on SSI, wife is fighting breast cancer, medical bills soaring!!

If you've lived there 2 out of the past 5 years then you are tax exempt on the first $250k of equity gain if you're single or $500k if you're married. 

There are only three exceptions outlined in the law:A. to any person with that person’s prior express invitation or permissionB. to any person with whom the caller has an established business relationshipC. by a tax exempt nonprofit organization.Here is the full text of the law.