The counties don't have zoning jurisdiction but you'll want to make sure you're filing quarterly tax reports with them (in Monroe and Carbon, for example), not only for their compliance but your township/HOA may require it as well.  

Can anyone send me a link to an amazon Smoke detector/ Carbon Monoxide that will pass a Smoke Certification in Massachusetts? 

Quote from @John Carbone: Quote from @John Underwood: It's only worth what comparable sales say they are worth.

(a) Security deposits for residential dwelling units shall be permitted only for the following:(1) The tenant's possible nonpayment of rent and costs for water or sewer services provided pursuant to G.S. 62-110(g) and electric service pursuant to G.S. 62-110(h).(2) Damage to the premises, including damage to or destruction of smoke alarms or carbon monoxide alarms.(3) Damages as the result of the nonfulfillment of the rental period, except where the tenant terminated the rental agreement under G.S. 42-45, G.S. 42-45.1, or because the tenant was forced to leave the property because of the landlord's violation of Article 2A of Chapter 42 of the General Statutes or was constructively evicted by the landlord's violation of G.S. 42-42(a).(4) Any unpaid bills that become a lien against the demised property due to the tenant's occupancy.(5) The costs of re-renting the premises after breach by the tenant, including any reasonable fees or commissions paid by the landlord to a licensed real estate broker to re-rent the premises.(6) The costs of removal and storage of the tenant's property after a summary ejectment proceeding.(7) Court costs.(8) Any fee permitted by G.S. 42-46.Source: North Carolina Tenant Security Deposit Act

Thanks @John Carbone but I don't think that my place fits the avatar of what you mentioned above where I would agree that 1 bathroom is less of an issue.

A bad HVAC install w/o proper venting install could cause a carbon monoxide issue. 

Quote from @John Carbone: Perhaps this works is specific locations, but someone here in the smoky mountains built 3 treehouses, ,and for the most part they did a really good job on it.....result has been a disaster.

Quote from @John Carbone: Quote from @Luke Carl: No one is going to rent a 20k house for 2 nights.

Quote from @John Carbone: Coffeyville, Kansas Coffeyville, Kansas Coffeyville, Kansas Coffeyville, Kansas Coffeyville, Kansas  What's pushing the STR market there?

Quote from @John Carbone: Quote from @Venkateswaran Venkatasubramanian: I am an investor wholives outside of Gatlinburg and I am keen to invest in the short-term rental(STR) market, specifically in luxury turnkey properties.