I know of a couple factors, such as, employment rates and population growth, but that's about it. 

OK, inflation in general, the supply crisis, low interest rates and a growing population also have something to do with it.

If the price is relatively low/sqft and the city has a growing population and job market, the demand for homes will increase which leads to home appreciation.

I want to start in OKC, but I'm open to Tulsa, Broken Arrow, and other highly populated areas in Oklahoma. 

Since Nashville is a fast-growing city and a lot of population coming in, we believe the house is in the desirable market. 

We have other goals, but that's the goal with this first property.The house is an hour+ out of the Triangle but in a populated area.

Southeastern NC will offer better opportunities in general for employment due to the population numbers.

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Would be glad to have a conversation with you.As far as Indianapolis vs the rest of the state -- look at the economic stability and population growth.Climate - our winters are milder here than Chicago area, tornadoes are rare, more common is hail and wind storms so plan for roof insurance claims for that.The numbers do work here in a landlord friendly state with low property taxes (2% of assessed value).

To answer your question more specifically, you should be looking at crime maps, discussing with your real estate agent (who's not allowed to tell you what is a 'good neighborhood' but can tell you where people are buying - hence moving, looking at the population growth of the area, and looking for any new employers coming to the town.