I know how we handle this issue in our own house, but that requires us to occasionally dispose of a dead mouse, something a vacationer is not going to want to do. 

I just want to try out STR at some point because that will be my primary weapon of choice to get a place in Maui paid off by vacationers, and would rather have some experience doing it first.

They tend to be the party crowd and can be a menace to the other vacationers who are paying top dollar to stay in a really nice hotel/area. 

Air conditioning (vacationers).  

The neighborhoods we are either completely or mostly STR's.If every city did it this way, there would not be so many issues.I think that what is eventually going to happen is that the cities that do it right and that have a reason for tourists to visit will end up becoming much more attractive to vacationers than cities that don't.

I know it is illegal to discriminate, but has anyone purposely created a STR for physically handicapped vacationers?

However, i did not find this to be easy......until I found Airbnb.Airbnb markets to vacationers, business travelers, etc.   

We found that the majority of HomeAway guests in our properties around the country are one week vacationers once or twice a year.

Other areas to look at would be near Siesta Key, Long Boat Key, etc... they are nice areas with frequent vacationers

@Mark S. also makes an excellent point that we probably don't even want to deal with the vacationers taking the cheapest options.