There are only minor administrative differences in working with S-8 tenants.

A loan is non taxable yet all the responses keep referring to a taxable distribution with fed state and 10% penalty which makes a distribution a horrible idea.401k loan can be taken in two flavors 5 year term personal and or if you can document its a primary residence you can get a 15 year fixed which makes the cashflow deduction from your paystubs a bearable proposition since a 5 year term presents a much higher payment.You can borrow 50k or 50% whichever is less at rates around 1 + prime (3.25% since 2009).You end up paying yourself a 4.25% rate interest and in essence become your own private bank.The funds are paid back to yourself with after tax dollars deducted from your biweekly or no monthly pay.Hope that clarifies, I've had borrowers use 401k loans from a variety of administrators such as fidelity, vanguard, nationwide, ING, prudential, and etc and I've seen them bein used for purchase or refinance on primary residences.

Of course, my example assumes there is a property management company in place that is handling all administrative and management duties of the business. 

I basically do all the administration work for both businesses, manage and do some of the rehabs on new purchases, much of the property maintenance, etc.

A simple IRR calculation with data based on long-term trends, true economic vacancy, and timing of capex will put you way ahead of most people analyzing investments.

Back in the day, I had a friend who was a database engineer.

Having a strong handle on lease administration is critical.  

My wife and I do finances for the Small Business Administration Covid relief program, so we have an excellent insider look at the books of many American businesses.

I will like to know how you guys think his administration will affect Real Estate and Investors. 

I currently manage all 90 rentals myself, although I do have a 3hr/wk person administrate billing/mail.